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Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model.

Abstract
Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono-L-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.
AuthorsTakuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Hiroshi Moritake, Tohru Sugimoto, Toshiko Sakuma, Toshihiro Akisue, Shinji Kawabata, Mitsunori Kirihata, Minoru Suzuki, Yoshinori Sakurai, Koji Ono, Yoshinobu Fukumori, Masahiro Kurosaka, Hideki Ichikawa
JournalApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 73 Pg. 96-100 (Mar 2013) ISSN: 1872-9800 [Electronic] England
PMID23306161 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Topics
  • Animals
  • Boron Neutron Capture Therapy (methods)
  • Cell Line, Tumor
  • Female
  • Histocytochemistry
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Sarcoma, Clear Cell (radiotherapy)
  • Soft Tissue Neoplasms (radiotherapy)
  • Xenograft Model Antitumor Assays

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