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Exploiting specific interactions toward next-generation polymeric drug transporters.

Abstract
A generic method describes advanced tailoring of polymer drug carriers based on polymer-block-peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble and enable precise adjustment of drug-release profiles beyond established block-copolymer carriers. While proof of principle is shown on chlorin as a partially approved drug for photodynamic cancer therapy, the concept is universal and applies to a broad spectrum of difficult drugs.
AuthorsSebastian Wieczorek, Eberhard Krause, Steffen Hackbarth, Beate Röder, Anna K H Hirsch, Hans G Börner
JournalJournal of the American Chemical Society (J Am Chem Soc) Vol. 135 Issue 5 Pg. 1711-4 (Feb 06 2013) ISSN: 1520-5126 [Electronic] United States
PMID23305453 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • Mesoporphyrins
  • Peptides
  • Polymers
  • temoporfin
Topics
  • Antineoplastic Agents (chemistry)
  • Drug Carriers (chemistry)
  • Mesoporphyrins (chemistry)
  • Models, Molecular
  • Molecular Structure
  • Peptides (chemistry, genetics)
  • Photochemotherapy
  • Polymers (chemistry)

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