Abstract |
A generic method describes advanced tailoring of polymer drug carriers based on polymer-block- peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble and enable precise adjustment of drug-release profiles beyond established block-copolymer carriers. While proof of principle is shown on chlorin as a partially approved drug for photodynamic cancer therapy, the concept is universal and applies to a broad spectrum of difficult drugs.
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Authors | Sebastian Wieczorek, Eberhard Krause, Steffen Hackbarth, Beate Röder, Anna K H Hirsch, Hans G Börner |
Journal | Journal of the American Chemical Society
(J Am Chem Soc)
Vol. 135
Issue 5
Pg. 1711-4
(Feb 06 2013)
ISSN: 1520-5126 [Electronic] United States |
PMID | 23305453
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Drug Carriers
- Mesoporphyrins
- Peptides
- Polymers
- temoporfin
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Topics |
- Antineoplastic Agents
(chemistry)
- Drug Carriers
(chemistry)
- Mesoporphyrins
(chemistry)
- Models, Molecular
- Molecular Structure
- Peptides
(chemistry, genetics)
- Photochemotherapy
- Polymers
(chemistry)
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