Abstract | AIM: The aim of this randomized controlled clinical trial was to evaluate the clinical effects of chlorhexidine (CHX) application in a full-mouth disinfection ( FMD) protocol in poorly controlled type-2 diabetic subjects with generalized chronic periodontitis. MATERIAL AND METHODS: Thirty-eight subjects were randomly assigned into FMD group (n=19): full-mouth scaling and root planing (FMSRP) within 24 h + local application of CHX gel + CHX rinses for 60 days or Control group (n = 19): FMSRP within 24 h + local application of placebo gel + placebo rinses for 60 days. Clinical parameters, glycated haemoglobin and fasting plasma glucose were assessed at baseline, 3, 6 and 12 months post- therapies. RESULTS: All clinical parameters improved significantly at 3, 6 and 12 months post- therapies for both groups (p < 0.05). There were no significant differences between groups for any clinical parameters, and glycemic condition at any time-point (p > 0.05). CONCLUSIONS: The treatments did not differ with respect to clinical parameters, including the primary outcome variable (i.e. changes in clinical attachment level in deep pockets), for up to 12 months post-treatments.
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Authors | Vanessa R Santos, Jadson A Lima, Tamires S Miranda, Tiago E D Gonçalves, Luciene C Figueiredo, Marcelo Faveri, Poliana M Duarte |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 40
Issue 2
Pg. 155-62
(Feb 2013)
ISSN: 1600-051X [Electronic] United States |
PMID | 23305133
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 John Wiley & Sons A/S. |
Chemical References |
- Anti-Infective Agents, Local
- Gels
- Glycated Hemoglobin A
- Chlorhexidine
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Topics |
- Adult
- Aged
- Analysis of Variance
- Anti-Infective Agents, Local
(blood, therapeutic use)
- Chlorhexidine
(therapeutic use)
- Chronic Periodontitis
(complications, drug therapy)
- Dental Scaling
- Diabetes Mellitus, Type 2
(complications, drug therapy, metabolism)
- Female
- Gels
- Glycated Hemoglobin
(analysis)
- Humans
- Male
- Middle Aged
- Periodontal Attachment Loss
(pathology)
- Prospective Studies
- Single-Blind Method
- Statistics, Nonparametric
- Treatment Outcome
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