HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Actin binding proteins: their ups and downs in metastatic life.

Abstract
In order to metastasize away from the primary tumor site and migrate into adjacent tissues, cancer cells will stimulate cellular motility through the regulation of their cytoskeletal structures. Through the coordinated polymerization of actin filaments, these cells will control the geometry of distinct structures, namely lamella, lamellipodia and filopodia, as well as the more recently characterized invadopodia. Because actin binding proteins play fundamental functions in regulating the dynamics of actin polymerization, they have been at the forefront of cancer research. This review focuses on a subset of actin binding proteins involved in the regulation of these cellular structures and protrusions, and presents some general principles summarizing how these proteins may remodel the structure of actin. The main body of this review aims to provide new insights into how the expression of these actin binding proteins is regulated during carcinogenesis and highlights new mechanisms that may be initiated by the metastatic cells to induce aberrant expression of such proteins.
AuthorsStephane R Gross
JournalCell adhesion & migration (Cell Adh Migr) 2013 Mar-Apr Vol. 7 Issue 2 Pg. 199-213 ISSN: 1933-6926 [Electronic] United States
PMID23302954 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Actin-Related Protein 2-3 Complex
  • Carrier Proteins
  • DNA-Binding Proteins
  • MicroRNAs
  • Microfilament Proteins
  • RNA-Binding Proteins
  • Tropomyosin
  • Wiskott-Aldrich Syndrome Protein
  • ZBP1 protein, human
  • fascin
Topics
  • Actin Cytoskeleton (metabolism)
  • Actin-Related Protein 2-3 Complex (metabolism)
  • Carrier Proteins (metabolism)
  • Cell Movement
  • DNA-Binding Proteins (metabolism)
  • Humans
  • MicroRNAs (genetics, metabolism)
  • Microfilament Proteins (metabolism)
  • Neoplasm Metastasis
  • Neoplasms (metabolism, pathology)
  • Pseudopodia (metabolism)
  • RNA-Binding Proteins
  • Tropomyosin (metabolism)
  • Wiskott-Aldrich Syndrome Protein (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: