Abstract | BACKGROUND: OBJECTIVE: To investigate the impact of lactation duration on insulin and glucose response among women with prior GDM. DESIGN/METHODS: The study group comprised 144 women with a history of GDM between 2003 and 2010. Plasma insulin and glucose concentrations were obtained from a 75 g oral glucose tolerance test (OGTT). Total lactation duration (exclusive breastfeeding and breast and bottle-feeding) for all infants was self-reported in months. RESULTS: Mean age was 36.5±5.0 years. Time between delivery and metabolic testing was 4.0±1.9 years. Women breastfed for an average of 13.9±16.8 months. Most women (80.6%) reported a history of lactation. Women who lactated had higher homeostasis model assessment for insulin sensitivity (HOMA-IS) and Matsuda indices and lower fasting and 2-h post-OGTT insulin concentrations as well as area under the curve (AUC) for insulin (P≤0.01 for all). Compared with women who lactated for <10 months, women who lactated for ≥10 months had improved insulin sensitivity-secretion index, higher HOMA-IS and Matsuda indices, lower fasting and 2-h post-OGTT insulin concentrations as well as AUC for insulin, and lower incidence of impaired glucose intolerance (P≤0.05 for all). In multiple linear regression analyses, lactation duration emerged as an independent predictor of fasting insulin concentrations (β=-0.02) and insulin sensitivity indices (β=0.02) (P≤0.05 for all). CONCLUSIONS: These results suggest that longer duration of lactation is associated with improved insulin and glucose response among women with prior GDM.
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Authors | Sarah Chouinard-Castonguay, S John Weisnagel, André Tchernof, Julie Robitaille |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 168
Issue 4
Pg. 515-23
(Apr 2013)
ISSN: 1479-683X [Electronic] England |
PMID | 23302255
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Breast Feeding
(trends)
- Diabetes, Gestational
(epidemiology, metabolism)
- Female
- Humans
- Infant
- Infant, Newborn
- Insulin
(metabolism)
- Lactation
(metabolism)
- Pregnancy
- Surveys and Questionnaires
- Time Factors
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