Abstract |
In the present study, we investigated the changes in both anti-HAV lgG and anti-HBs lgG levels and compared the antibody seroconversion rates of different doses of combined hepatitis A and hepatitis B vaccine in children. Children who were vaccinated as infants with Hepatitis B vaccine were revaccinated at 5-15 y of age, then the antibody titers were monitored. Among 283 children, this study found that the anti-HAV seroconversion rates (defined as anti-HAV ≥ 1 mIU/ml) after the first and the third dose were 79.9% and 100% respectively; these observed differences were statistically significant (P<0.05); the corresponding geometric mean titers (GMTs) were 4.72 ± 2.63 mIU/ml and 13.46 ± 1.16 mIU/ml respectively. The anti-HBs seroconversion rates (defined as an anti-HBs ≥ 10 mIU/ml) were 82.3% and 99.0% respectively; these observed differences were statistically significant (P<0.05); and the corresponding titers were 319.95 ± 5.16 mIU/ml and 418.59 ± 3.89 mIU/ml respectively. After the first booster dose, the difference in anti-HAV seroconversion rate was statistically significant in children aged 5-9 y and 10-15 y (P<0.05), as was the difference of anti-HBs seroconversion, whereas after the third dose the difference was not statistically significant (P>0.05). This study demonstrated that the immunization effects of booster vaccination with combined hepatitis A and hepatitis B vaccine is successful for children. A single booster dose is adequate for younger children, while three doses are needed for older children.
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Authors | Yongdi Chen, Hua Gu, Suyun Cheng, Lingzhi Shen, Fujiang Cui, Fuzhen Wang, Jun Yao, Shichang Xia, Huakun Lv, Xiaofeng Liang |
Journal | Human vaccines & immunotherapeutics
(Hum Vaccin Immunother)
Vol. 9
Issue 4
Pg. 898-902
(Apr 2013)
ISSN: 2164-554X [Electronic] United States |
PMID | 23295964
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hepatitis A Antibodies
- Hepatitis A Vaccines
- Hepatitis B Antibodies
- Hepatitis B Vaccines
- Immunoglobulin G
- Vaccines, Combined
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Hepatitis A Antibodies
(blood)
- Hepatitis A Vaccines
(administration & dosage, immunology)
- Hepatitis B Antibodies
(blood)
- Hepatitis B Vaccines
(administration & dosage, immunology)
- Humans
- Immunization, Secondary
(methods)
- Immunoglobulin G
(blood)
- Male
- Time Factors
- Vaccines, Combined
(administration & dosage, immunology)
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