Abstract | OBJECTIVES: METHODS: A historical cohort study of Olmsted County, Minnesota residents diagnosed with collagenous or lymphocytic colitis (LC) between 1986 and 2010 was performed using the Rochester Epidemiology Project. RESULTS: Of 315 patients with MC, 80 (25.4%) were treated with corticosteroids. The median age at colitis diagnosis was 66.5 years (range: 16-95) and 78.7% were female. Forty patients (50%) had LC and 40 (50%) had collagenous colitis. Prednisone was used in 17 patients (21.2%) and budesonide in 63 (78.8%); 56 (75.6%) had complete response and 15 (20.3%) had partial response. Patients treated with budesonide had a higher rate of complete response than those treated with prednisone (82.5 vs. 52.9%; odds ratio, 4.18; 95% CI, 1.3-13.5). Six patients were lost to follow-up. The remaining 74 had a median follow-up of 4 years (range 0.2-14). Fifty patients out of the 71 who responded (70.4%) had a recurrence after corticosteroid discontinuation. Patients treated with budesonide were less likely to recur than those treated with prednisone (hazard ratio, 0.38; 95% CI, 0.18-0.85; P=0.02). After 397 person years of follow-up in the 73 patients with long-term data, 47 (64.4%) required maintenance with corticosteroids. CONCLUSION:
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Authors | Nicole M Gentile, Adil A Abdalla, Sahil Khanna, Thomas C Smyrk, William J Tremaine, William A Faubion, Patricia P Kammer, William J Sandborn, Edward V Loftus Jr, Darrell S Pardi |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 108
Issue 2
Pg. 256-9
(Feb 2013)
ISSN: 1572-0241 [Electronic] United States |
PMID | 23295275
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Gastrointestinal Agents
- Budesonide
- Prednisone
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Topics |
- Adolescent
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents
(therapeutic use)
- Budesonide
(therapeutic use)
- Chronic Disease
- Cohort Studies
- Colitis, Microscopic
(drug therapy, epidemiology, pathology, prevention & control)
- Disease-Free Survival
- Female
- Follow-Up Studies
- Gastrointestinal Agents
(therapeutic use)
- Humans
- Male
- Medical Records
- Middle Aged
- Minnesota
(epidemiology)
- Odds Ratio
- Prednisone
(therapeutic use)
- Proportional Hazards Models
- Retrospective Studies
- Secondary Prevention
- Time Factors
- Treatment Outcome
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