Abstract | INTRODUCTION:
Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers. Cathepsin B is normally associated with the lysosomes involved in autophagy and immune response, but its aberrant expression has been shown to lead to cancers. AREAS COVERED: EXPERT OPINION: Targeting cathepsin B alone does not appear to abolish tumor growth, and this is probably because cathepsin B appears to have diverse functions and influence numerous pathways. It is not clear whether global suppression of cathepsin B activity or expression would produce unintended effects or cause the activation or suppression of unwanted pathways. A localized approach for targeting the expression of cathepsin B would be more relevant. Moreover, a combination of targeting cathepsin B with other relevant oncogenic molecules has significant therapeutic potential.
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Authors | Christopher S Gondi, Jasti S Rao |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 17
Issue 3
Pg. 281-91
(Mar 2013)
ISSN: 1744-7631 [Electronic] England |
PMID | 23293836
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
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Topics |
- Animals
- Cathepsin B
(antagonists & inhibitors, metabolism)
- Humans
- Neoplasms
(drug therapy, metabolism)
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