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Cathepsin B as a cancer target.

AbstractINTRODUCTION:
Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers. Cathepsin B is normally associated with the lysosomes involved in autophagy and immune response, but its aberrant expression has been shown to lead to cancers.
AREAS COVERED:
This review highlights the oncogenic role of cathepsin B, discusses the regulation of cathepsin B in light of oncogenesis, discusses the role of cathepsin B as a signaling molecule, and highlights the therapeutic potential of targeting cathepsin B.
EXPERT OPINION:
Targeting cathepsin B alone does not appear to abolish tumor growth, and this is probably because cathepsin B appears to have diverse functions and influence numerous pathways. It is not clear whether global suppression of cathepsin B activity or expression would produce unintended effects or cause the activation or suppression of unwanted pathways. A localized approach for targeting the expression of cathepsin B would be more relevant. Moreover, a combination of targeting cathepsin B with other relevant oncogenic molecules has significant therapeutic potential.
AuthorsChristopher S Gondi, Jasti S Rao
JournalExpert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 17 Issue 3 Pg. 281-91 (Mar 2013) ISSN: 1744-7631 [Electronic] England
PMID23293836 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Cathepsin B
Topics
  • Animals
  • Cathepsin B (antagonists & inhibitors, metabolism)
  • Humans
  • Neoplasms (drug therapy, metabolism)

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