Abstract | OBJECTIVES: The aim of the study was to evaluate the lipid-lowering effects and clinical safety of a natural hypolipidemic compound, coenzyme A ( CoA) capsule, in Chinese patients with moderate dyslipidemia. METHODS: A total of 244 subjects (170 males and 74 females; aged 18-75 y) having moderate dyslipidemia ( triglyceride [TG], 2.3-6.5 mmol · L(-1)) were randomly divided into 3 groups, to which placebo (group A, n = 81), CoA 200 U/d (group B, n = 79), and CoA 400 U/d (group C, n = 84) were administered, respectively. Blood lipoproteins, liver and renal functions, blood glucose, and complete blood count were measured at the baseline and after 4 or 8 weeks of treatment. RESULTS:
After treatment for 4 weeks, TG was reduced by 5.1, 15.7, and 14.4% in groups A, B, and C, respectively. After treatment for 8 weeks, TG decreased .9, 21.7, and 36.1%, respectively. Compared with group A, the primary efficacy outcome TG in groups B and C significantly decreased (P < .01), and the difference between groups B and C was also significant (P < .01). Plasma total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were not significantly different. Furthermore, there was no difference in blood glucose, hepatic and renal function test parameters, incidence of myopathy, or gastrointestinal tract symptoms among the 3 groups. CONCLUSION:
CoA can effectively reduce plasma TG levels in subjects with moderate dyslipidemia and has no obvious adverse effect.
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Authors | Ya-qin Chen, Shui-ping Zhao, Jun-zhu Chen, Jiangtao Lai |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 98
Issue 2
Pg. E275-8
(Feb 2013)
ISSN: 1945-7197 [Electronic] United States |
PMID | 23293333
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Blood Glucose
- Lipids
- Coenzyme A
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Topics |
- Adolescent
- Adult
- Aged
- Anticholesteremic Agents
(pharmacology, therapeutic use)
- Blood Glucose
- Coenzyme A
(pharmacology, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hyperlipidemias
(blood, drug therapy, physiopathology)
- Kidney
(drug effects, physiopathology)
- Lipids
(blood)
- Liver
(drug effects, physiopathology)
- Male
- Middle Aged
- Treatment Outcome
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