Abstract | BACKGROUND:
Calciphylaxis is a life-threatening complication in patients with end-stage renal disease ( ESRD). No established therapy exists so far. The aim of the present study was to determine the therapeutic response to a multi-interventional treatment regimen with consistent use of sodium thiosulphate (STS) in an Austrian cohort of calciphylaxis patients. METHODS: We retrospectively collected demographic, clinical and laboratory data on 27 calciphylaxis patients treated with STS at seven Austrian dialysis centres between June 2004 and November 2010. RESULTS: Twenty-seven dialysis patients (68 ± 12 years) were treated with STS for a median (25th, 75th percentile) of 96 (54, 133) days. Seven patients (26%) suffered from proximal-type, and 20 patients (74%) from distal-type calciphylaxis. Fourteen patients (52%) showed a complete remission, five patients (19%) a partial remission and eight patients (30%) progression that resulted in amputation in four patients. During a median follow-up of 101 (79, 273) days, 14 patients died (52%). Non-survivors were older (P = 0.04), showed higher CRP values (P = 0.04), presented more frequently with proximal-type calciphylaxis (P = 0.03), had a higher disease severity score at diagnosis (P = 0.01), were treated more often with antibiotics (P = 0.01) and cinacalcet (P = 0.03) and had a lower remission rate during treatment (P = 0.004) than did survivors. The use of antibiotics and cinacalcet, disease severity at diagnosis and remission rates were found to be significant survival predictors in logistic regression analysis. CONCLUSIONS:
Calciphylaxis remains a serious complication with high mortality. Early and consistent therapy including STS may help to improve the disease outcome.
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Authors | Emanuel Zitt, Matthias König, Andreas Vychytil, Martin Auinger, Manfred Wallner, Gernot Lingenhel, Gernot Schilcher, Michael Rudnicki, Hermann Salmhofer, Karl Lhotta |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 28
Issue 5
Pg. 1232-40
(May 2013)
ISSN: 1460-2385 [Electronic] England |
PMID | 23291368
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chelating Agents
- Thiosulfates
- sodium thiosulfate
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Topics |
- Aged
- Calciphylaxis
(drug therapy, etiology, mortality)
- Chelating Agents
(therapeutic use)
- Female
- Follow-Up Studies
- Humans
- Kidney Failure, Chronic
(complications)
- Male
- Middle Aged
- Prognosis
- Renal Dialysis
(mortality)
- Retrospective Studies
- Survival Rate
- Thiosulfates
(therapeutic use)
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