Bilateral diffuse pigmented villonodular synovitis of the knee.

Abstract

Pigmented villonodular synovitis (PVNS) is a proliferative disease of synovial tissue characterized by lipid-laden macrophages, multinucleated giant cells, and hemosiderin deposits. PVNS presents either in a localized form with minimal rates of recurrence after surgical resection or in a diffuse form with an expansive growth pattern showing formation of osseous erosions and extra-articular manifestation. In the diffuse form high recurrence rates occur as a result of the challenge of achievement of total synovectomy. Typically only one single joint, being the knee in 80% of cases, is involved with diffuse PVNS. Reports of bi- or multiarticular manifestation are at best rare. Here, a case of a 16-year-old girl with bilateral diffuse PVNS of the knee allows discussion of diagnostic and treatment considerations.

• Authors: Georg Klammer, Michael Betz, Barbara Delaloye, Mazda Farshad, Koch P Peter
• Journal: The journal of knee surgery (J Knee Surg) Vol. 26 Suppl 1 Pg. S67-71 (Dec 2013) ISSN: 1538-8506 [Print] Germany
• PMID: 23288770 (Publication Type: Case Reports, Journal Article)
• Copyright: Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Chemical References

• Yttrium Radioisotopes

Topics

• Adolescent
• Female
• Humans
• Knee Joint (pathology)
• Magnetic Resonance Imaging
• Recurrence
• Synovectomy
• Synovial Membrane (radiation effects)
• Synovitis, Pigmented Villonodular (diagnosis, therapy)
• Yttrium Radioisotopes