[Usefulness of a scoring system on perinatal outcomes in pregnant women with thrombophilia in the effectiveness of an enoxaparin-based intervention].

Abstract

PURPOSES:

To assess whether an enoxaparin-based intervention using a score system was effective in improving perinatal outcome in women with thrombophilia.

METHODS:

STUDY DESIGN:

Prospective, not randomized, uncontrolled, performed at a Clinic of High-Risk Pregnancy from November 2009 to November 2011. We included women with a diagnosis and therapeutic intervention for thrombophilia acquired and/or inherited in the current pregnancy. The obstetric and perinatal outcomes of pregnant women before the intervention were compared with outcomes after the intervention, and statistically analyzed using the χ2 test with Yates correction, considered significant when p<0.05. The initial dose of low-molecular-weight Heparin (LMWH) was guided by a scoring system based on the clinical and gestational history of the patients and screening tests for acquired and/or inherited thrombophilia.

RESULTS:

We included 84 pregnant women with 175 pregnancies before diagnosis, 20.0% of which resulted in fetal ou perinatal death, 40.0% resulted in abortion, 17.7% developed preeclampsia/eclampsia, 10.3% resulted in full-term births, and 29.7% in premature births. In the 84 pregnancies after intervention, 6.0% resulted in fetal ou perinatal death, 1.2% in abortion, 4.8% developed preeclampsia/eclampsia, 22.6% resulted in premature birth, and 70.2% in full-term birth. A significant reduction in the rate of stillbirths/perinatal death (p<0.05) and abortion (p<0.0001) and a significant increase (p<0.05) in the number of live births were observed after intervention.

CONCLUSION:

Enoxaparin-based intervention using a score system in pregnant women with thrombophilia is effective in improving perinatal outcome.

• Authors: Ernesto Antonio Figueiró-Filho, Vanessa Marcon de Oliveira, Ili Breda, Lílian Rezende Coelho, Cristiane Munaretto Ferreira
• Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (Rev Bras Ginecol Obstet) Vol. 34 Issue 10 Pg. 459-65 (Oct 2012) ISSN: 1806-9339 [Electronic] Brazil
• Vernacular Title: Eficácia de intervenção com enoxaparina baseada em sistema de pontuação nos desfechos perinatais de gestantes com trombofilias.
• PMID: 23288223 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Enoxaparin

Topics

• Adult
• Anticoagulants (administration & dosage, therapeutic use)
• Enoxaparin (administration & dosage, therapeutic use)
• Female
• Humans
• Pregnancy
• Pregnancy Complications, Hematologic (classification, drug therapy)
• Pregnancy Outcome
• Prospective Studies
• Thrombophilia (classification, drug therapy)