[Meta-analysis of Shenmai injection treatment for acute myocardial infarction].

Abstract

OBJECTIVE:

To assess the efficacy and safety of Shenmai injection for acute myocardial infarction (AMI).

METHOD:

All clinical studies of Shenmai for AMI were searched from Cochrane library, Medline, EMbase, CBM, CNKI, Wanfang and VIP. For efficacy analysis of Shenmai, randomized controlled trials (RCTs) and quasi-RCTs were included and the Cochrane Collaboration's RevMan 5.1 was used for data analysis.

RESULT:

1) Fifty studies were included for efficacy analysis, in which, only 1 study was true RCT, all of studies did not mention allocation concealment, blind and information of loss to follow-up. The fatality rate during hospitalization (OR 0.43, 95% CI [0.31-0.60]), incidence of heart failure (OR 0.49, 95% CI [0.34-0.70]), incidence of shock (OR 0.53, 95% CI[0.30-0.93]) and incidence of re-infarction (OR 0.16, 95% CI [0.03-0.77]) in Shenmai injection plus conventional treatment group was lower than that in the conventional treatment group, while the rate of recanalization (OR 1.24, 95% CI [0.90-1.71]) was similar between the two groups. 2) For safety analysis, we did not found serious adverse drug reaction/adverse events (ADR/AE) of Shenmai injection for AMI.

CONCLUSION:

The currently available evidence showed that Shenmai injection plus conventional treatment group may decrease the fatality rate during hospitalization, the incidence of cardiac failure, shock and re-infarction. However, these findings should be carefully interpreted due to the low methodological quality and small sample size of trials. Although serious ADR/AE was did not report of Shenmai injection, the post-marketing safety evaluation is need to be performed.

• Authors: Jing Hu, Wen Zhang, Yan-Ming Xie, Lian-Xin Wang, Xiao-Lu Nie, Yue-Lun Zhang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 37 Issue 18 Pg. 2760-7 (Sep 2012) ISSN: 1001-5302 [Print] China
• PMID: 23285929 (Publication Type: English Abstract, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• fructus schizandrae, radix ginseng, radix ophiopogonis drug combination

Topics

• Adolescent
• Adult
• Aged
• Child
• Drug Combinations
• Drugs, Chinese Herbal (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Myocardial Infarction (drug therapy, mortality)
• Randomized Controlled Trials as Topic
• Treatment Outcome
• Young Adult