CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors.

Abstract

BACKGROUND:

Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes.

OBJECTIVE AND METHODS:

The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT).

RESULTS:

The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann-Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann-Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test).

CONCLUSION:

A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors.

• Authors: Leonardo Araújo Mello, Andréia Leal Figueiredo, Eduardo Antônio Gonçalves Ramos, Clarissa Araújo Silva Gurgel, Manoela Domingues Martins, Claúdia Roberta Leite Vieira de Figueiredo, Patrícia Ramos Cury, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Luciana Maria Pedreira Ramalho, Jean Nunes Dos Santos
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 42 Issue 6 Pg. 454-61 (Jul 2013) ISSN: 1600-0714 [Electronic] Denmark
• PMID: 23278770 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Antigens, CD1
• CD1a antigen
• Cadherins

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Ameloblastoma (pathology)
• Antigens, CD1 (analysis)
• Cadherins (analysis)
• Cell Adhesion (physiology)
• Cell Count
• Cell Shape
• Child
• Dendritic Cells (pathology)
• Epithelial Cells (pathology)
• Female
• Humans
• Immunohistochemistry
• Keratinocytes (pathology)
• Langerhans Cells (pathology)
• Male
• Mandibular Neoplasms (pathology)
• Maxillary Neoplasms (pathology)
• Middle Aged
• Odontogenic Cyst, Calcifying (pathology)
• Odontogenic Tumors (pathology)
• Young Adult