Abstract | AIM: METHODS: This retrospective study included 44 participants in a 12-month period, who were divided in two groups: group A - in which propafenone caused complete ventriculo-atrial block and group B - in which propafenone did not cause complete ventriculo-atrial block. RESULTS: Group A had significantly lower incidence of tachycardia than group B (95% vs 70.8%, P=0.038), and complete ventriculo-atrial block predicted the efficacy of propafenone oral therapy in the prevention of tachycardia (sensitivity 87.5%, specificity 52.8%, positive predictive value 95%, negative predictive value 29.2%). Patients with AVNRT in group B who did not experience the recurrences of tachycardia had significantly shorter echo zone before intravenous administration of propafenone than the patients who experienced episodes of sustained tachycardia (median 40 ms [range 15-60 ms] vs 79 ms [range 50-180 ms], P=0.008). CONCLUSION: In patients with non-inducible tachycardia, complete ventriculo-atrial block can be used as an electrophysiological predictor of the efficacy of propafenone oral therapy in the prevention of tachycardia. In patients with non-inducible AVNRT, but without complete ventriculo-atrial block, propafenone was more effective in patients with shorter echo zone of tachycardia.
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Authors | Hrvoje Pintarić, Ivan Zeljković, Zdravko Babić, Mislav Vrsalović, Nikola Pavlović, Hrvojka Bosnjak, Dubravko Petrac |
Journal | Croatian medical journal
(Croat Med J)
Vol. 53
Issue 6
Pg. 605-11
(Dec 2012)
ISSN: 1332-8166 [Electronic] Croatia |
PMID | 23275326
(Publication Type: Journal Article)
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Chemical References |
- Anti-Arrhythmia Agents
- Propafenone
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Topics |
- Adult
- Aged
- Anti-Arrhythmia Agents
(adverse effects, therapeutic use)
- Atrioventricular Node
(drug effects)
- Electrocardiography
- Electrophysiologic Techniques, Cardiac
- Female
- Humans
- Incidence
- Injections, Intravenous
- Male
- Middle Aged
- Propafenone
(adverse effects, therapeutic use)
- Retrospective Studies
- Tachycardia, Atrioventricular Nodal Reentry
(physiopathology, prevention & control)
- Tachycardia, Supraventricular
(physiopathology, prevention & control)
- Treatment Outcome
- Young Adult
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