Abstract |
Sepsis, a serious unbalanced hyperinflammatory condition, is a tremendous burden for healthcare systems, with a high mortality and limited treatment. Increasing evidences indicated that some active components derived from natural foods have potent anti-inflammatory properties. Here we show that mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya, attenuates cecal ligation and puncture-induced mortality and acute lung injury (ALI), as indicated by reduced systemic and pulmonary inflammatory responses. Moreover, pretreatment with MF inhibits sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, resulting in inhibiting production of proinflammatory mediators. Notably, MF dose-dependently up-regulates the expression and activity of heme oxygenase (HO)-1 in the lung of septic mice. Further, these beneficial effects of MF on the septic lung injury were eliminated by ZnPP IX, a specific HO-1 inhibitor. Our results suggest that MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators. Thereby, MF may be effective in treating sepsis with ALI.
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Authors | Xia Gong, Li Zhang, Rong Jiang, Mengliang Ye, Xinru Yin, Jingyuan Wan |
Journal | The Journal of nutritional biochemistry
(J Nutr Biochem)
Vol. 24
Issue 6
Pg. 1173-81
(Jun 2013)
ISSN: 1873-4847 [Electronic] United States |
PMID | 23266284
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Xanthones
- mangiferin
- Heme Oxygenase-1
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Topics |
- Acute Lung Injury
(drug therapy, etiology, metabolism)
- Animals
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Cecum
(pathology)
- Constriction, Pathologic
- Heme Oxygenase-1
(genetics, metabolism)
- Inflammation
(drug therapy, metabolism)
- Lung
(metabolism, pathology)
- Mice
- Mice, Inbred BALB C
- Sepsis
(complications, metabolism)
- Up-Regulation
- Xanthones
(pharmacology, therapeutic use)
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