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Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1.

Abstract
Sepsis, a serious unbalanced hyperinflammatory condition, is a tremendous burden for healthcare systems, with a high mortality and limited treatment. Increasing evidences indicated that some active components derived from natural foods have potent anti-inflammatory properties. Here we show that mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya, attenuates cecal ligation and puncture-induced mortality and acute lung injury (ALI), as indicated by reduced systemic and pulmonary inflammatory responses. Moreover, pretreatment with MF inhibits sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, resulting in inhibiting production of proinflammatory mediators. Notably, MF dose-dependently up-regulates the expression and activity of heme oxygenase (HO)-1 in the lung of septic mice. Further, these beneficial effects of MF on the septic lung injury were eliminated by ZnPP IX, a specific HO-1 inhibitor. Our results suggest that MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators. Thereby, MF may be effective in treating sepsis with ALI.
AuthorsXia Gong, Li Zhang, Rong Jiang, Mengliang Ye, Xinru Yin, Jingyuan Wan
JournalThe Journal of nutritional biochemistry (J Nutr Biochem) Vol. 24 Issue 6 Pg. 1173-81 (Jun 2013) ISSN: 1873-4847 [Electronic] United States
PMID23266284 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Xanthones
  • mangiferin
  • Heme Oxygenase-1
Topics
  • Acute Lung Injury (drug therapy, etiology, metabolism)
  • Animals
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Cecum (pathology)
  • Constriction, Pathologic
  • Heme Oxygenase-1 (genetics, metabolism)
  • Inflammation (drug therapy, metabolism)
  • Lung (metabolism, pathology)
  • Mice
  • Mice, Inbred BALB C
  • Sepsis (complications, metabolism)
  • Up-Regulation
  • Xanthones (pharmacology, therapeutic use)

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