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Successful transplantation of ethnically mismatched cord blood in a boy with atypical chronic myeloid leukemia.

Abstract
In the present study, we describe unrelated umbilical cord blood transplantation (CBT) in a 7-year-old Taiwanese boy with atypical chronic myeloid leukemia (BCR-ABL 1 negative). Physical examination was notable for splenomegaly. Cytogenetic analyses from the bone marrow revealed a t(3;5)(p21;q31) translocation. The patient then underwent CBT from an HLA-mismatched (two loci by serotype, three loci by genotype) unrelated donor of Caucasian origin. Times to neutrophil and platelet engraftment were 21 and 62 days post-transplant, respectively. Acute graft-versus-host disease following transplantation was minimal. The patient remains in continuing hematological remission with full donor chimerism 28 months after transplantation.
AuthorsTang-Her Jaing, Iou-Jih Hung, Shih-Hsiang Chen, Wen-I Lee, Yu-Chuan Wen, En-Chen Fang
JournalInternational journal of hematology (Int J Hematol) Vol. 97 Issue 1 Pg. 144-6 (Jan 2013) ISSN: 1865-3774 [Electronic] Japan
PMID23264127 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Child
  • Cord Blood Stem Cell Transplantation
  • Humans
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (diagnosis, therapy)
  • Male
  • Remission Induction
  • Transplantation Conditioning
  • Transplantation, Homologous
  • Treatment Outcome

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