Abstract |
In the present study, we describe unrelated umbilical cord blood transplantation (CBT) in a 7-year-old Taiwanese boy with atypical chronic myeloid leukemia (BCR-ABL 1 negative). Physical examination was notable for splenomegaly. Cytogenetic analyses from the bone marrow revealed a t(3;5)(p21;q31) translocation. The patient then underwent CBT from an HLA-mismatched (two loci by serotype, three loci by genotype) unrelated donor of Caucasian origin. Times to neutrophil and platelet engraftment were 21 and 62 days post-transplant, respectively. Acute graft-versus-host disease following transplantation was minimal. The patient remains in continuing hematological remission with full donor chimerism 28 months after transplantation.
|
Authors | Tang-Her Jaing, Iou-Jih Hung, Shih-Hsiang Chen, Wen-I Lee, Yu-Chuan Wen, En-Chen Fang |
Journal | International journal of hematology
(Int J Hematol)
Vol. 97
Issue 1
Pg. 144-6
(Jan 2013)
ISSN: 1865-3774 [Electronic] Japan |
PMID | 23264127
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Child
- Cord Blood Stem Cell Transplantation
- Humans
- Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
(diagnosis, therapy)
- Male
- Remission Induction
- Transplantation Conditioning
- Transplantation, Homologous
- Treatment Outcome
|