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Experimental infection of pregnant cows with noncytopathogenic bovine viral diarrhoea virus between days 26 and 50 postbreeding.

Abstract
The effect of bovine viral diarrhoea virus (BVDV) infection on early pregnant cows between 10 and 24 days after virus inoculation at day 26 of pregnancy was determined. Four cows were inoculated intravenously with either BVDV (treated, n=3) or growth medium (control, n=1). The treated cows were euthanized on either day 10, 17 or 24 post-infection and the control cow was euthanized on day 24 post-infection. The level of serum 2-5A synthetase increased in all of the three treated cows. Progesterone levels decreased to below 1.0 ng/ml between 10 and 22 days after inoculation in two of the three treated cows and the embryos/foetuses of two cows died. Therefore, BVDV may be a cause of early embryonic or feotal loss in early pregnant cows and serum 2-5A synthetase may be useful as an indicator of viral infection in cows.
AuthorsT Tsuboi, T Osawa, T-I Hirata, K Kawashima, K Kimura, M Haritani
JournalResearch in veterinary science (Res Vet Sci) Vol. 94 Issue 3 Pg. 803-5 (Jun 2013) ISSN: 1532-2661 [Electronic] England
PMID23261157 (Publication Type: Journal Article)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Progesterone
  • 2',5'-Oligoadenylate Synthetase
Topics
  • 2',5'-Oligoadenylate Synthetase (blood)
  • Abortion, Septic (veterinary, virology)
  • Animals
  • Bovine Virus Diarrhea-Mucosal Disease (blood, pathology, virology)
  • Cattle
  • Diarrhea Viruses, Bovine Viral
  • Female
  • Pregnancy
  • Pregnancy Complications, Infectious (blood, pathology, veterinary, virology)
  • Progesterone (blood)

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