Abstract | BACKGROUND:
Vitamin D has anti-inflammatory and antimicrobial properties that, together with its influence on bone health, may confer periodontal benefit. METHODS: Cross-sectional associations (years 1997-2000) between plasma 25-hydroxyvitamin D concentration [25( OH)D] and periodontal measure were investigated among 920 postmenopausal women. Measures of chronic disease were defined based on: 1) alveolar crestal height (ACH) measures from intraoral radiographs and tooth loss and 2) Centers for Disease Control and Prevention (CDC)/American Academy of Periodontology ( AAP) criteria using measures of clinical attachment level and probing depth (PD). Acute oral inflammation was assessed by the percentage of gingival sites that bled upon assessment with a probe. Logistic regression was used to estimate the odds ratios ( ORs) and 95% confidence intervals (CIs) for periodontal disease among participants with adequate [25( OH)D ≥50 nmol/L] compared with deficient/inadequate [25( OH)D <50 nmol/L] vitamin D status adjusted for age, dental visit frequency, and body mass index. RESULTS: No association was observed between vitamin D status and periodontal disease defined by ACH and tooth loss (adjusted OR = 0.96, 95% CI = 0.68 to 1.35). In contrast, women with adequate compared with deficient/inadequate vitamin D status had 33% lower odds (95% CI = 5% to 53%) of periodontal disease according to the CDC/ AAP definition and 42% lower odds (95% CI = 21% to 58%) of having ≥50% of gingival sites that bled. CONCLUSIONS:
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Authors | Amy E Millen, Kathleen M Hovey, Michael J LaMonte, Mya Swanson, Christopher A Andrews, Melissa A Kluczynski, Robert J Genco, Jean Wactawski-Wende |
Journal | Journal of periodontology
(J Periodontol)
Vol. 84
Issue 9
Pg. 1243-56
(Sep 2013)
ISSN: 1943-3670 [Electronic] United States |
PMID | 23259413
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Vitamin D
- 25-hydroxyvitamin D
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Topics |
- Absorptiometry, Photon
- Age Factors
- Aged
- Alveolar Bone Loss
(classification)
- Body Mass Index
- Chronic Periodontitis
(blood, classification)
- Cross-Sectional Studies
- Dental Care
(statistics & numerical data)
- Dental Plaque
(microbiology)
- Female
- Gingival Hemorrhage
(classification)
- Humans
- Middle Aged
- Motor Activity
- Periodontal Attachment Loss
(classification)
- Periodontal Pocket
(classification)
- Postmenopause
(blood)
- Smoking
- Tooth Loss
(classification)
- Vitamin D
(analogs & derivatives, blood)
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