Comparison of transdermal electromotive administration of verapamil and dexamethasone versus intra-lesional injection for Peyronie's disease.

Abstract

To compare the efficacy of transdermal electromotive administration and intra-lesional injection of verapamil plus dexamethasone for the treatment of Peyronie's disease. Patients with Peyronie's disease of less than 2-year duration were randomized into two groups of transdermal electromotive administration and intra-lesional injection of verapamil plus dexamethasone. During the 6-week therapy period, a single weekly dose of 10 mg verapamil and 4 mg dexamethasone solution was administered to 30 patients in each group either by transdermal electromotive method or via the conventional injection method by a syringe connected to a 25 G needle. Evaluations of plaque length, width, and volume, penile curvature, erectile dysfunction and penile deviations were carried out before and after 1 and 3 months of the interventions. Erectile pain was reduced in the electromotive group from a mean of 5.1-1.0 in scale of 10 and from 5.4 to 3.6 in the injection group (p = 0.006). Regarding plaque length, plaque width, penile curvature plaque volume and erectile dysfunction, the electromotive administration group showed better results which, however, were not statistically significant. (p > 0.05). Transdermal electromotive drug administration yielded comparable results as against current conventional intra-lesional injection technique and fared better in controlling erectile pain.

• Authors: A R Mehrsai, F Namdari, A Salavati, S Dehghani, F Allameh, G Pourmand
• Journal: Andrology (Andrology) Vol. 1 Issue 1 Pg. 129-32 (Jan 2013) ISSN: 2047-2927 [Electronic] England
• PMID: 23258641 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: © 2012 American Society of Andrology and European Academy of Andrology.

Chemical References

• Calcium Channel Blockers
• Glucocorticoids
• Dexamethasone
• Verapamil

Topics

• Administration, Cutaneous
• Analysis of Variance
• Calcium Channel Blockers (administration & dosage)
• Dexamethasone (administration & dosage)
• Drug Therapy, Combination
• Glucocorticoids (administration & dosage)
• Humans
• Injections, Intralesional
• Iontophoresis
• Iran
• Male
• Penile Induration (diagnosis, drug therapy)
• Prospective Studies
• Time Factors
• Treatment Outcome
• Verapamil (administration & dosage)