Abstract | OBJECTIVE: METHODS: Sixty-three patients with silicosis were randomly divided into treatment group (n = 33) and control group ( n = 30). Both groups received anti-inflammatory, cough-relieving, and anti-asthmatic treatment. Meanwhile, the treatment group was given tetrandrine tablets (100 mg bid) and matrine injection (150 mg qd). There were 4 courses of tetrandrine treatment (each course = 3 months), with one-month intervals among them. Matrine injection was used for 15 consecutive days in each month. There were 2 courses of matrine treatment (each course = 3 months), with a one-month interval in between. The clinical symptoms, pulmonary function, serum superoxide dismutase (SOD) activity, and chest X-ray images were observed before and after treatment. RESULTS:
After treatment, chest distress, chest pain, shortness of breath, and other respiratory symptoms were relieved significantly (P < 0.05). The treatment group showed significantly higher SOD activity than before treatment and the control group (P < 0.05) and significantly higher forced vital capacity and forced expiratory volume in one second than before treatment and the control group (P < 0.05). After treatment, 5 patients (4 stage II cases and 1 stage III case, all in rapidly progressive forms) in the treatment group showed smaller, lighter, and clearer shadows with decreased overall intensity on chest X-ray; 12 patients showed significantly fewer and clearer lung markings on chest X-ray. CONCLUSION:
|
Authors | Rong-ming Miao, Zhong-hua Fang, Yongming Yao |
Journal | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
(Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi)
Vol. 30
Issue 10
Pg. 778-80
(Oct 2012)
ISSN: 1001-9391 [Print] China |
PMID | 23257008
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Alkaloids
- Benzylisoquinolines
- Quinolizines
- Tablets
- tetrandrine
- Matrines
|
Topics |
- Aged
- Alkaloids
(administration & dosage, therapeutic use)
- Benzylisoquinolines
(administration & dosage, therapeutic use)
- Humans
- Injections
- Male
- Middle Aged
- Quinolizines
(administration & dosage, therapeutic use)
- Silicosis
(drug therapy)
- Tablets
- Treatment Outcome
- Matrines
|