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[Therapeutic efficacy of tetrandrine tablets combined with matrine injection in treatment of silicosis].

AbstractOBJECTIVE:
To observe the therapeutic efficacy of tetrandrine tablets combined with matrine injection in the treatment of silicosis.
METHODS:
Sixty-three patients with silicosis were randomly divided into treatment group (n = 33) and control group (n = 30). Both groups received anti-inflammatory, cough-relieving, and anti-asthmatic treatment. Meanwhile, the treatment group was given tetrandrine tablets (100 mg bid) and matrine injection (150 mg qd). There were 4 courses of tetrandrine treatment (each course = 3 months), with one-month intervals among them. Matrine injection was used for 15 consecutive days in each month. There were 2 courses of matrine treatment (each course = 3 months), with a one-month interval in between. The clinical symptoms, pulmonary function, serum superoxide dismutase (SOD) activity, and chest X-ray images were observed before and after treatment.
RESULTS:
After treatment, chest distress, chest pain, shortness of breath, and other respiratory symptoms were relieved significantly (P < 0.05). The treatment group showed significantly higher SOD activity than before treatment and the control group (P < 0.05) and significantly higher forced vital capacity and forced expiratory volume in one second than before treatment and the control group (P < 0.05). After treatment, 5 patients (4 stage II cases and 1 stage III case, all in rapidly progressive forms) in the treatment group showed smaller, lighter, and clearer shadows with decreased overall intensity on chest X-ray; 12 patients showed significantly fewer and clearer lung markings on chest X-ray.
CONCLUSION:
Tetrandrine tablets combined with matrine injection have some therapeutic effect on silicosis.
AuthorsRong-ming Miao, Zhong-hua Fang, Yongming Yao
JournalZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 30 Issue 10 Pg. 778-80 (Oct 2012) ISSN: 1001-9391 [Print] China
PMID23257008 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Alkaloids
  • Benzylisoquinolines
  • Quinolizines
  • Tablets
  • tetrandrine
  • Matrines
Topics
  • Aged
  • Alkaloids (administration & dosage, therapeutic use)
  • Benzylisoquinolines (administration & dosage, therapeutic use)
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Quinolizines (administration & dosage, therapeutic use)
  • Silicosis (drug therapy)
  • Tablets
  • Treatment Outcome
  • Matrines

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