Abstract | RATIONALE: METHODS: IDO activity and cytokine concentrations in sputum supernatants from patients with COPD of varying severity and in smoking and non-smoking control subjects were determined by high-performance liquid chromatography and ELISA, respectively. RESULTS: Patients with COPD had reduced sputum IDO activity and expression and IL-10 levels, with increased IL-17A, IL-6 and CXCL8 concentrations and sputum neutrophils. These changes were significantly correlated with disease severity. IDO activity was decreased, but to a lesser extent, in normal smokers compared with non-smoking controls. CONCLUSIONS: Patients with COPD have a progressive reduction in IDO activity with reversal of the balance between IL-10 and IL-17A, resulting in chronic airway neutrophilic inflammation.
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Authors | Kittipong Maneechotesuwan, Kanda Kasetsinsombat, Adisak Wongkajornsilp, Peter J Barnes |
Journal | Thorax
(Thorax)
Vol. 68
Issue 4
Pg. 330-7
(Apr 2013)
ISSN: 1468-3296 [Electronic] England |
PMID | 23255616
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IL17A protein, human
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Interleukin-17
- Interleukin-6
- Interleukin-8
- Interleukin-10
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Topics |
- Disease Progression
- Female
- Humans
- Indoleamine-Pyrrole 2,3,-Dioxygenase
(metabolism)
- Interleukin-10
(metabolism)
- Interleukin-17
(metabolism)
- Interleukin-6
(metabolism)
- Interleukin-8
(metabolism)
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(metabolism)
- Sputum
(metabolism)
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