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A comparative pilot study of symptom improvement before and after phototherapy in Korean patients with perennial allergic rhinitis.

Abstract
Although allergic rhinitis is not life threatening, it significantly influences the quality of a patient's life. This study is intended to evaluate the safety and efficacy of phototherapy with low-level energy of a 650 nm laser irradiation system in perennial allergic rhinitis patients. This clinical trial was an open-label, single-center study with 42 perennial allergic rhinitis subjects. Following laser irradiation in the nasal cavity with a laser irradiation system, the efficacy at weeks 1 through 4 was determined. The symptoms were scored with four parameters (nasal obstruction, rhinorrhea, sneezing and itching) before and after illumination of the laser, and the total score was recorded. A survey of Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was conducted by patients before and after treatment. Following treatment, significant improvement in the clinical symptoms of nasal obstruction (P < 0.001), rhinorrhea (P = 0.005), sneezing (P = 0.001) and itching (P = 0.003) was reported by 68% of perennial allergic rhinitis patients. The overall RQLQ scores significantly improved by 45% from the baseline with the treatment after 4 weeks. These results indicate that phototherapy is an effective modality for treating perennial allergic rhinitis and is another option in the steroid-free management of immune-mediated mucosal diseases.
AuthorsHeung-Man Lee, Man Sik Park, Il Ho Park, Seung Hoon Lee, Seong Keon Lee, Kyu-Sung Kim, Hyuk Choi
JournalPhotochemistry and photobiology (Photochem Photobiol) 2013 May-Jun Vol. 89 Issue 3 Pg. 751-7 ISSN: 1751-1097 [Electronic] United States
PMID23253070 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2013 The American Society of Photobiology.
Topics
  • Adult
  • Female
  • Humans
  • Low-Level Light Therapy
  • Male
  • Middle Aged
  • Nasal Obstruction (physiopathology)
  • Pilot Projects
  • Pruritus (physiopathology)
  • Quality of Life
  • Republic of Korea
  • Rhinitis, Allergic, Perennial (physiopathology, radiotherapy)
  • Sneezing
  • Surveys and Questionnaires
  • Treatment Outcome

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