Abstract | UNLABELLED: METHODS: RESULTS: 1) Procalcitonin was significantly higher in patients with pleural infection compared with controls with non-infective effusions (n = 32 each group) that were case-matched for systemic inflammation as measured by CRP [median (25-75%IQR): 0.58 (0.35-1.50) vs 0.34 (0.31-0.42) µg/L respectively, p = 0.003]. 2) Talc pleurodesis provoked intense systemic inflammation, and raised serum CRP by 360% over baseline. However procalcitonin remained relatively unaffected (21% rise). 3) Procalcitonin and CRP levels did not correlate. In 214 patients with pleural infection, procalcitonin levels did not predict the survival or need for surgical intervention. CONCLUSION:
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Authors | Fiona J McCann, Stephen J Chapman, Wai Cho Yu, Nick A Maskell, Robert J O Davies, Y C Gary Lee |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 12
Pg. e49894
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23251353
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers
- CALCA protein, human
- Protein Precursors
- Calcitonin
- Calcitonin Gene-Related Peptide
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Calcitonin
(blood)
- Calcitonin Gene-Related Peptide
- Diagnosis, Differential
- Female
- Humans
- Infections
(blood, diagnosis)
- Inflammation
(blood, diagnosis)
- Male
- Middle Aged
- Pleura
(metabolism)
- Pleural Diseases
(blood, diagnosis)
- Protein Precursors
(blood)
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