Abstract | BACKGROUND: METHODS: Eight groups (n=6) of normal Sprague-Dawley rats were studied: four groups received tacrolimus, sirolimus, tacrolimus/ sirolimus, or control for 14 days, and four more groups received similar treatments along with metformin. Daily glucoses were measured. All rats were administered an oral glucose challenge before sacrifice. Pancreata were analyzed by terminal deoxynucleotide tranferase-mediated dUTP nick-end labeling staining and immunohistochemistry. RESULTS: CONCLUSIONS: This is the first study to show that metformin can improve immunosuppressant-induced hyperglycemia, when administered concurrently, and reduces exocrine apoptosis (reducing the impact on potential islet progenitor cells).
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Authors | Vijay Shivaswamy, Robert G Bennett, Cara C Clure, Jennifer L Larsen, Frederick G Hamel |
Journal | Transplantation
(Transplantation)
Vol. 95
Issue 2
Pg. 280-4
(Jan 27 2013)
ISSN: 1534-6080 [Electronic] United States |
PMID | 23250335
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Biomarkers
- Blood Glucose
- Hypoglycemic Agents
- Immunosuppressive Agents
- Insulin
- Metformin
- Sirolimus
- Tacrolimus
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Topics |
- Animals
- Apoptosis
(drug effects)
- Biomarkers
(blood)
- Blood Glucose
(drug effects, metabolism)
- Disease Models, Animal
- Glucose Tolerance Test
- Hyperglycemia
(blood, chemically induced, drug therapy, pathology)
- Hyperinsulinism
(blood, chemically induced)
- Hypoglycemic Agents
(pharmacology)
- Immunohistochemistry
- Immunosuppressive Agents
- In Situ Nick-End Labeling
- Insulin
(blood)
- Male
- Metformin
(pharmacology)
- Pancreas, Exocrine
(drug effects, metabolism, pathology)
- Rats
- Rats, Sprague-Dawley
- Sirolimus
- Tacrolimus
- Time Factors
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