HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Is altered BDNF biosynthesis a general feature in patients with cognitive dysfunctions?

Abstract
Severe cognitive deficits are a frequent outcome of both neurodegenerative and neurodevelopmental disorders. In the attempt to define new clinical biomarkers, current research trends aim at the identification of common molecular features in these pathologies rather than searching for differences. Brain-derived neurotrophic factor (BDNF) has attracted great interest as possible biomarker because of its key role in synaptic remodeling during cognitive processes. BDNF undergoes proteolytic processing and studies in animal models have highlighted that different forms of learning and memory require either the proBDNF precursor or the mature BDNF form. Significantly, an altered expression of BDNF forms was found in postmortem brains and serum from patients with schizophrenia, Alzheimer's disease and mood disorders. Based on these studies, this review puts forward the hypothesis that abnormalities in proBDNF or mBDNF biosynthesis may correspond to different cognitive dysfunctions in these brain diseases, while the role of truncated BDNF remains unknown.
AuthorsDavide Carlino, Maurizio De Vanna, Enrico Tongiorgi
JournalThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry (Neuroscientist) Vol. 19 Issue 4 Pg. 345-53 (Aug 2013) ISSN: 1089-4098 [Electronic] United States
PMID23242909 (Publication Type: Journal Article, Review)
Chemical References
  • Biomarkers
  • Brain-Derived Neurotrophic Factor
Topics
  • Animals
  • Biomarkers (blood)
  • Brain-Derived Neurotrophic Factor (biosynthesis, blood, metabolism)
  • Cognition Disorders (blood, metabolism, physiopathology)
  • Humans
  • Learning (physiology)
  • Memory (physiology)
  • Mice
  • Mice, Knockout

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: