Three cases of perioral dermatitis related to fusobacteria treated with β-lactam antibiotics.

Abstract

BACKGROUND:

The oral tetracyclines, especially minocycline hydrochloride, are often used as an effective treatment for perioral dermatitis; however, they are sometimes difficult to use, especially in children, because of the side effects.

OBJECTIVE:

The effectiveness of β-lactam antibiotics was evaluated in three cases of perioral dermatitis.

METHODS:

Three Japanese patients with perioral dermatitis were treated with cefcapene pivoxil hydrochloride hydrate per os 100-300 mg/day. They were one girl (aged 10 years) and two adult women (aged 32 and 37 years respectively). One of the adult patients had a past history of Meniere's disease and the other had had a side effect, vertigo, from minocycline hydrochloride treatment. The presence of fusobacteria before and after the treatment was examined using the tape-stripping toluidine blue method.

RESULTS:

These patients showed the improvement in 1-2 weeks and were much improved or cured after 2-5 weeks. No side effects were found during the treatment. Fusobacteria were positive before treatment but became negative after the treatment in all of them.

CONCLUSION:

The β-lactam antibiotics might be a useful treatment for perioral dermatitis, especially in cases who cannot take tetracyclines.

• Authors: Naoko Ishiguro, Azusa Maeda, Kaoru Suzuki, Yayoi Yamana, Yasuko Fukuya, Makoto Kawashima
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 25 Issue 6 Pg. 507-9 (Dec 2014) ISSN: 1471-1753 [Electronic] England
• PMID: 23240905 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• beta-Lactams
• cefcapene pivoxil hydrochloride

Topics

• Administration, Oral
• Adult
• Anti-Bacterial Agents (administration & dosage, adverse effects)
• Cephalosporins (administration & dosage, adverse effects)
• Child
• Dermatitis, Perioral (drug therapy, etiology, microbiology)
• Female
• Fusobacterium Infections (drug therapy)
• Humans
• Treatment Outcome
• beta-Lactams (administration & dosage, adverse effects)