Botulinum toxin injections combined with or without sodium hyaluronate in the absence of electromyography for the treatment of infantile esotropia: a pilot study.

Abstract

OBJECTIVE:

To evaluate the feasibility and safety of a revised technique of botulinum toxin type A (BTA) injections for the treatment of infantile esotropia.

METHODS:

Forty-seven patients with infantile esotropia were randomly divided into two groups. In group A, 23 cases were treated with a bilateral injection of 2.5-3.75 U BTA combined with sodium hyaluronate (SH) to the medial rectus muscle. In group B, 24 cases were treated with a bilateral injection of 2.5-3.75 U BTA solution alone to the medial rectus muscle. Electromyography was not used in the study. All patients received one injection and were evaluated 2 weeks, 3 months, and 6 months following injection.

RESULTS:

The measured changes between groups A and B included the frequencies of good alignment 6 months after injections (30.4% vs 37.5%), complicated ptosis (2.2% vs 20.8%), and vertical deviation (2.2% vs 2.1%).

CONCLUSION:

BTA injections combined with or without SH in the absence of electromyography demonstrated effectiveness and feasibility in the treatment of infantile esotropia. A relative decrease in the frequency of complicated ptosis resulted from injections of BTA+SH.

• Authors: J Chen, D Deng, H Zhong, X Lin, Y Kang, H Wu, J Yan, G Mai
• Journal: Eye (London, England) (Eye (Lond)) Vol. 27 Issue 3 Pg. 382-6 (Mar 2013) ISSN: 1476-5454 [Electronic] England
• PMID: 23238444 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Neuromuscular Agents
• Viscosupplements
• Hyaluronic Acid
• Botulinum Toxins, Type A

Topics

• Botulinum Toxins, Type A (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Drug Therapy, Combination
• Electromyography
• Esotropia (drug therapy, physiopathology)
• Feasibility Studies
• Female
• Humans
• Hyaluronic Acid (adverse effects, therapeutic use)
• Infant
• Injections, Intramuscular
• Male
• Neuromuscular Agents (adverse effects, therapeutic use)
• Oculomotor Muscles (drug effects, physiopathology)
• Pilot Projects
• Treatment Outcome
• Viscosupplements (adverse effects, therapeutic use)
• Vision, Binocular (physiology)
• Visual Acuity (physiology)