Abstract | BACKGROUND: CLINICAL CASES: patient 1 with follicular NHL, GI, intermediate FLIPI, CD20+, CD45+, BCL-2+, who reached complete response after three chemotherapy regimes. Mobilization failed after use of filgrastim ( G-CSF) alone and G-CSF + cyclophosphamide. A new attempt was made with G-CSF + plerixafor ( G-CSF, 10 μg/kg for 7 days + plerixafor, 240 μg/kg in days 4 to 7). Patient 2 with follicular NHL and CD20+ reached complete remission with MINE after therapeutic failure with other regimes, but develops severe marrow toxicity. Mobilization was supported with G-CSF 10 μg/kg/d + plerixafor in days 4 and 5. In case one, proper cell counts where obtained after three aphaeresis. In the second case, two harvests add of 2.7 × 106/kg were obtained. CONCLUSIONS:
plerixafor raised the hematopoietic stem cells in peripheral blood and improves mobilization of proper cell population.
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Authors | Uendy Pérez-Lozano, Francisco Tripp-Villanueva, Aline Ramírez-Alvarado, Jorge Vela-Ojeda, Alejandro Limón-Flores, José Luis Kramis-Cerezo |
Journal | Revista medica del Instituto Mexicano del Seguro Social
(Rev Med Inst Mex Seguro Soc)
2012 Jul-Aug
Vol. 50
Issue 4
Pg. 449-51
ISSN: 0443-5117 [Print] Mexico |
Vernacular Title | Movilización de células hematopoyéticas con plerixafor en linfoma no Hodgkin folicular. |
PMID | 23234751
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Benzylamines
- Cyclams
- Heterocyclic Compounds
- plerixafor
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Topics |
- Adult
- Benzylamines
- Cyclams
- Hematopoietic Stem Cell Mobilization
(methods)
- Heterocyclic Compounds
(therapeutic use)
- Humans
- Lymphoma, Non-Hodgkin
(drug therapy)
- Male
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