Abstract | AIM: SUBJECTS AND METHODS: One hundred and eighty-one patients with IS were examined; all the patients received TLT. Fibrinogen concentrations were determined by the Clauss method on admission, immediately after TLT, and daily during the first 7 days of observation; the efficacy of thrombolysis was evaluated using the NIH stroke scale every day, the Rankin scale, and the Barthel Index on days 14 and 21. RESULTS: The patients with a fibrinogen concentration of below 330 mg/dl showed the lowest frequency of asymptomatic HT (AHT) as hemorrhagic stroke (HS) type 1 in the absence of clinically worsening HT (CWHT), as well as FO and the highest rate of good functional recovery. Those with a fibrinogen concentration of 330-385 mg/dl most commonly displayed AHT as HS types 1 and 2 equally frequently, as well as the highest frequency of a positive effect according to the criteria for good and/or satisfactory functional recoveries. The fibrinogen concentration range of 385-423 mg/dl compared to the above range was characterized by an increased risk for AHT as HS type 2, for CWHT as equally distributed parenchymal hematoma types 1 and 2, by higher death rates and less chance of functional recovery. The elevated fibrinogen concentration above 423 mg/dl was accompanied by high death rates and CWHT as parenchymal hematoma type 2 and the higher frequency of poor outcome in the evaluation of functional recovery. CONCLUSION: The revealed three threshold fibrinogen concentrations of 330, 385, and 423 mg/dl allow one to predict HS, FO, and the efficiency of TLT in patients with IS.
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Authors | O V Liang, A G Kochetov, N A Shamalov, K V Anisimov, G R Ramazanov, A A Arkhipkin, Iu V Novozhenova, M A Kustova, D C Podshivalov, V O Egorov |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 84
Issue 10
Pg. 42-7
( 2012)
ISSN: 0040-3660 [Print] Russia (Federation) |
PMID | 23227499
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Fibrinolytic Agents
- Fibrinogen
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Topics |
- Aged
- Brain Ischemia
(blood, drug therapy, mortality)
- Female
- Fibrinogen
- Fibrinolytic Agents
(administration & dosage, adverse effects)
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Recovery of Function
- Severity of Illness Index
- Stroke
(blood, drug therapy, mortality)
- Thrombolytic Therapy
(adverse effects, methods)
- Treatment Outcome
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