Abstract | BACKGROUND: METHODS: N-WASP expression was first analyzed by Western blotting in 19 paired HCC and paratumoral liver (PTL) tissues. We further evaluated N-WASP expression immunohistochemically in samples from 119 patients with HCC. The clinicopathologic and prognostic importance of N-WASP expression were also investigated. RESULTS: Western blotting showed that N-WASP expression was up-regulated in 15 of 19 HCC tissues (79%), compared with PTL ones. The N-WASP-positive rate in immunohistochemical staining also was greater in HCC (63/119, 53%) than that in PTL tissues (8/119, 6%). The up-regulated N-WASP expression in HCC tissues was correlated with absence of capsule formation and predicted less overall and disease-free survival. Multivariate analysis demonstrated that N-WASP was an independent prognostic factor for overall survival and was marginally important for disease-free survival. CONCLUSION: These data establish that N-WASP is highly expressed in HCC and its strong prognostic importance. Therefore, the gene/ protein might serve as a potential therapeutic target for HCC.
|
Authors | Ke-Min Jin, Min Lu, Fang-Fang Liu, Jin Gu, Xiao-Juan Du, Bao-Cai Xing |
Journal | Surgery
(Surgery)
Vol. 153
Issue 4
Pg. 518-25
(Apr 2013)
ISSN: 1532-7361 [Electronic] United States |
PMID | 23218879
(Publication Type: Journal Article)
|
Copyright | Copyright © 2013 Mosby, Inc. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- WASL protein, human
- Wiskott-Aldrich Syndrome Protein, Neuronal
|
Topics |
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Blotting, Western
- Carcinoma, Hepatocellular
(metabolism, pathology)
- Female
- Humans
- Immunohistochemistry
- Liver Neoplasms
(metabolism, pathology)
- Male
- Middle Aged
- Prognosis
- Up-Regulation
- Wiskott-Aldrich Syndrome Protein, Neuronal
(metabolism)
|