P63 expression in papillary cystadenoma and mucoepidermoid carcinoma of minor salivary glands.

Abstract

OBJECTIVE:

The aim of this study was to investigate the expression of p63 protein in mucoepidermoid carcinoma and papillary cystadenoma of the salivary glands, and to evaluate the usefulness of this protein in distinguishing these tumors.

STUDY DESIGN:

Immunoexpression of p63 protein was studied and quantified in 9 formalin-fixed paraffin-embedded mucous retention cysts, 4 papillary cystadenomas, and 19 low-grade and 9 high-grade mucoepidermoid carcinomas.

RESULTS:

All cases were positive for p63 immunoexpression; however, it was observed that p63 labeling in mucous retention cysts and papillary cystadenomas was limited to the basal layers of the cystic spaces, whereas in low-grade mucoepidermoid carcinomas, positive nuclear staining was also found diffusely in the suprabasal layers. Mucoepidermoid carcinoma presented increased immunoexpression of p63 compared with the other groups.

CONCLUSIONS:

P63 immunohistochemical expression pattern can be helpful in distinguishing low-grade mucoepidermoid carcinoma from papillary cystadenoma of the salivary glands.

• Authors: Felipe Paiva Fonseca, Bruno Augusto Benevenuto de Andrade, Márcio Ajudarte Lopes, Hélder Antônio Rebelo Pontes, Pablo Agustin Vargas, Oslei Paes de Almeida
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 115 Issue 1 Pg. 79-86 (Jan 2013) ISSN: 2212-4411 [Electronic] United States
• PMID: 23217538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• TP63 protein, human
• Transcription Factors
• Tumor Suppressor Proteins

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Analysis of Variance
• Biomarkers, Tumor (metabolism)
• Carcinoma, Mucoepidermoid (metabolism, pathology)
• Cystadenoma, Papillary (metabolism, pathology)
• Female
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Salivary Gland Neoplasms (metabolism, pathology)
• Salivary Glands, Minor (pathology)
• Transcription Factors (metabolism)
• Tumor Suppressor Proteins (metabolism)