p120-Catenin: a novel regulator of innate immunity and inflammation.

Abstract

p120-Catenin is the prototypic member of a subfamily of armadillo repeat domain proteins. Like its structural homologues, β- and γ-catenin, p120-catenin is an essential component of adherens junctions in endothelial cells and other polarized adherent cells. p120-Catenin binds directly to the cytoplasmic domain of cadherin and contributes to the regulation of cell-cell junctional integrity. Studies have demonstrated that p120-catenin plays important roles in cell-cell adhesion, embryonic development, cell proliferation and polarity, tumor cell migration, and cancer progression. However, recent insights have generated an entirely new perspective, suggesting that p120-catenin is implicated in the anti-inflammatory responses in the absence and presence of infection. This review summarizes the present knowledge and recent progress toward elucidating the novel role of p120-catenin in the regulation of innate immunity and inflammation.

• Authors: Guochang Hu
• Journal: Critical reviews in immunology (Crit Rev Immunol) Vol. 32 Issue 2 Pg. 127-38 ( 2012) ISSN: 1040-8401 [Print] United States
• PMID: 23216611 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Armadillo Domain Proteins
• Catenins
• Desmosomal Cadherins
• Delta Catenin
• CTNND1 protein, human

Topics

• Adherens Junctions
• Animals
• Armadillo Domain Proteins (immunology, metabolism)
• Catenins (metabolism)
• Cell Adhesion
• Desmosomal Cadherins (metabolism)
• Endothelial Cells (immunology, metabolism)
• Humans
• Immunity, Innate
• Immunomodulation
• Inflammation (metabolism)
• Delta Catenin