Abstract | BACKGROUND AND AIM: Although non-steroidal anti-inflammatory drugs can induce intestinal injury, the mechanisms are not fully understood, and treatment has yet to be established. Heme oxygenase-1 (HO-1) has recently gained attention for anti-inflammatory and cytoprotective effects. This study aimed to investigate the effects of hemin, an HO-1 inducer, on indomethacin-induced enteritis in mice. METHODS: RESULTS: CONCLUSIONS: Induction of HO-1 by hemin inhibits indomethacin-induced intestinal injury through upregulation of HO-1. Pharmacological induction of HO-1 may offer a novel therapeutic strategy to prevent indomethacin-induced small intestinal injury.
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Authors | Hiroyuki Yoriki, Yuji Naito, Tomohisa Takagi, Katsura Mizusima, Yasuko Hirai, Akihito Harusato, Shinya Yamada, Toshifumi Tsuji, Munehiro Kugai, Akifumi Fukui, Yasuki Higashimura, Kazuhiko Katada, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Nobuaki Yagi, Hiroshi Ichikawa, Toshikazu Yosikawa |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 28
Issue 4
Pg. 632-8
(Apr 2013)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 23216607
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Chemokines
- Cytokines
- DNA Primers
- Enzyme Inhibitors
- Metalloporphyrins
- Protoporphyrins
- RNA, Messenger
- Hemin
- tin protoporphyrin IX
- Heme Oxygenase-1
- Indomethacin
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Topics |
- Animals
- Blotting, Western
- Chemokines
(genetics)
- Cytokines
(genetics)
- DNA Primers
(chemistry)
- Disease Models, Animal
- Enteritis
(chemically induced, enzymology, pathology, prevention & control)
- Enzyme Inhibitors
(pharmacology)
- Gene Expression Regulation
- Heme Oxygenase-1
(antagonists & inhibitors, metabolism)
- Hemin
(administration & dosage, therapeutic use)
- Immunohistochemistry
- Indomethacin
(toxicity)
- Intestine, Small
(drug effects)
- Male
- Metalloporphyrins
(pharmacology)
- Mice
- Mice, Inbred C57BL
- Protoporphyrins
(pharmacology)
- RNA, Messenger
(metabolism)
- Real-Time Polymerase Chain Reaction
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