[Efficacy of 153Sm-EDTMP in the treatment of prostate cancer with bone metastasis].

To investigate the efficacy of 153Sm-EDTMP in the treatment of bone metastasis of prostate cancer (PCa) by comparison with zoledronic acid.
We assigned 55 PCa patients with bone metastasis to receive 153Sm-EDTMP (n = 31) and zoledronic acid (n = 24), the former injected intravenously at the dose of 37.0 MBq/kg body weight, and the latter administered by slow intravenous drip at 4 mg in 100 ml of 0.9% sodium chloride. We performed 99mTc-MDP bone scan before and 1 -2 months after the treatment.
The rate of pain relief was 83.9% in the 153Sm-EDTMP group and 58.3% in the zoledronic acid group (P = 0.035), and that of bone metabolism change was 64.5% in the former and 33.3% in the latter (P = 0.022).
153Sm-EDTMP is an ideal agent for the treatment of prostate cancer with bone metastasis.
AuthorsJuan-Yi Feng, Chuang-Qi Wu, Peng Zhang, She-Jiao Wang, Xiang-Hong Zheng
JournalZhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 18 Issue 11 Pg. 982-5 (Nov 2012) ISSN: 1009-3591 [Print] China
PMID23214246 (Publication Type: Controlled Clinical Trial, Journal Article)
Chemical References
  • Diphosphonates
  • Imidazoles
  • Organometallic Compounds
  • Organophosphorus Compounds
  • Zoledronic Acid
  • samarium Sm-153 lexidronam
  • Aged
  • Aged, 80 and over
  • Bone Neoplasms (drug therapy, secondary)
  • Diphosphonates (therapeutic use)
  • Humans
  • Imidazoles (therapeutic use)
  • Male
  • Middle Aged
  • Neoplasm Metastasis (drug therapy)
  • Organometallic Compounds (therapeutic use)
  • Organophosphorus Compounds (therapeutic use)
  • Prostatic Neoplasms (drug therapy, pathology)
  • Zoledronic Acid

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