Abstract |
Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplementation of BB-4 reduced lipid peroxidation, decreased apoptosis, and increased GR and SOD activities in rat testis under hypobaric hypoxia conditions (P < 0.05). Therefore, this study demonstrates that blueberry extract significantly reduced the harmful effects of oxidative stress caused by hypobaric hypoxia in rat testis by affecting glutathione reductase and superoxide dismutase activities.
|
Authors | Andrea Zepeda, Luis G Aguayo, Jorge Fuentealba, Carolina Figueroa, Alejandro Acevedo, Perla Salgado, Gloria M Calaf, Jorge Farías |
Journal | Oxidative medicine and cellular longevity
(Oxid Med Cell Longev)
Vol. 2012
Pg. 975870
( 2012)
ISSN: 1942-0994 [Electronic] United States |
PMID | 23213351
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Plant Extracts
- Protective Agents
- Thiobarbituric Acid Reactive Substances
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione Reductase
|
Topics |
- Animals
- Blueberry Plants
(chemistry)
- Body Weight
(drug effects)
- Glutathione Peroxidase
(metabolism)
- Glutathione Reductase
(metabolism)
- Hematocrit
- Hypoxia
(enzymology, pathology, prevention & control)
- Lipid Peroxidation
(drug effects)
- Male
- Organ Size
(drug effects)
- Oxidative Stress
(drug effects)
- Plant Extracts
(pharmacology)
- Protective Agents
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(metabolism)
- Testis
(drug effects, enzymology, pathology)
- Thiobarbituric Acid Reactive Substances
(metabolism)
|