Motility disorders of the colon and rectum.

Abstract

PURPOSE OF REVIEW:

Symptoms associated with disorders of the motility of colon and rectum are common problems in clinical practice. Advances in this field continue to expand our understanding of these disorders and provide new and different treatments with promising results.

RECENT FINDINGS:

This article reviews new advances in the past year on the measurement and diagnosis of colonic transit. Recently published data question the importance of dietary fiber in the prevention of colonic diverticulosis and diverticulitis, and support the efficacy of a number of different therapies aimed at improving colonic motility and visceral sensation in constipation and reversing the effects of opioid induced constipation with peripherally acting opioid antagonists.

SUMMARY:

The articles referenced in this review help inform the reader on new developments in the diagnosis and management of patients with colonic and rectal motility disorders.

• Authors: Beatriz Gras, Suma Magge, Andrea Bloom, Anthony Lembo
• Journal: Current opinion in gastroenterology (Curr Opin Gastroenterol) Vol. 29 Issue 1 Pg. 66-71 (Jan 2013) ISSN: 1531-7056 [Electronic] United States
• PMID: 23207598 (Publication Type: Journal Article, Review)

Chemical References

• Dipeptides
• Gastrointestinal Agents
• Narcotic Antagonists
• Peptides
• Piperidines
• Quaternary Ammonium Compounds
• Thiazepines
• methylnaltrexone
• Naltrexone
• alvimopan
• elobixibat
• Tryptophan Hydroxylase
• linaclotide

Topics

• Constipation (diagnosis, drug therapy)
• Diet (adverse effects)
• Dipeptides (therapeutic use)
• Diverticulosis, Colonic (etiology)
• Gastrointestinal Agents (therapeutic use)
• Gastrointestinal Transit
• Humans
• Naltrexone (analogs & derivatives, therapeutic use)
• Narcotic Antagonists (therapeutic use)
• Peptides (therapeutic use)
• Piperidines (therapeutic use)
• Quaternary Ammonium Compounds (therapeutic use)
• Rectal Diseases (diagnosis, drug therapy)
• Thiazepines (therapeutic use)
• Tryptophan Hydroxylase (antagonists & inhibitors)