[Advancement of research on polyamidoamine dendrimers].

Abstract

Polyamidoamine (PAMAM) dendrimers is synthesized by the American scientist, Tomalia, in 1985 and is now used widely in many fields such as gene carriers, photoelectric sensor, wastewater treatment, drug carriers and catalyst. The present paper mainly reviews the structure and methods of synthesis, celluar cytotoxicity, achievements of gene and drug carriers research, advancement and prospect of PAMAM as a carrier in glioma therapy. Besides, it also involves an outline for the future research of the radiotherapy for glioma.

• Authors: Jing Xu, Longzhen Zhang
• Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi) Vol. 29 Issue 5 Pg. 1003-6 (Oct 2012) ISSN: 1001-5515 [Print] China
• PMID: 23198450 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Biocompatible Materials
• Dendrimers
• Drug Carriers
• PAMAM Starburst

Topics

• Biocompatible Materials (chemical synthesis, chemistry)
• Dendrimers (chemical synthesis, chemistry)
• Drug Carriers
• Genetic Vectors