Abstract |
Lymphocytes from a patient with classic galactosemia ( GALT deficiency) were hybridized with a Chinese hamster cell line. Electrophoretic valuation of GALT in 31 independently derived interspecific hybrid clones failed to demonstrate expression of the human GALT gene even when human chromosome 9 was present. Possible mechanisms for this lack of expression are presented.
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Authors | R S Sparkes, T Mohandas, M C Sparkes, J D Shulkin |
Journal | Biochemical genetics
(Biochem Genet)
Vol. 17
Issue 7-8
Pg. 683-92
(Aug 1979)
ISSN: 0006-2928 [Print] United States |
PMID | 231967
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Nucleotidyltransferases
- UTP-Hexose-1-Phosphate Uridylyltransferase
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Topics |
- Animals
- Cell Line
- Chromosome Mapping
- Chromosomes, Human, 6-12 and X
- Clone Cells
- Cricetinae
- Cricetulus
- Galactosemias
(genetics)
- Genes
- Humans
- Hybrid Cells
- Lymphocytes
- Nucleotidyltransferases
(genetics)
- UTP-Hexose-1-Phosphate Uridylyltransferase
(genetics)
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