[The analysis of hepatitis delta virus infective markers in the hepatitis is B virus infective people].

Abstract

OBJECTIVE:

To investigate the distribution of hepatitis delta virus (HDV) marker among hepatitis B virus (HBV) infected patients and to reveal its clinical significance.

METHOD:

To collect the clinical data and sera samples of HBV infected patients and to detect HDAg, Anti-HDV as well as HBV infection markers by means of enzyme-linked immunosorbnent assay. These data combined with clinical diagnostic results and biochemical index were then analyzed.

RESULT:

462 samples of HBV infected patients were collected including 210 HBV carriers without symptom, 175 chronic HBV infections, 35 acute HBV infections and 42 liver fibrosis. The HDV infection rate was 4.8% overall. The highest infection rate of 9.5% was found in the group of liver fibrosis whereas the lower rate of 6.9% was found in HBV chronic carriers. HDV infection rate was 7.8% among the population of 40-60 years old, obviously higher than any other age groups.

CONCLUSION:

HDV infection was significantly higher in the chronic HBV patients and liver fibrosis patients. Because HDV infection was highly associated with the progress of liver disease, we suggest the screen of HDV markers among hepatitis patients and discriminate whether the patient was co-infected with HDV.

• Authors: Po-Shi Xu, Shuang-Yin Han, Chang-Yi Sun, Jing Zhao
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 26 Issue 4 Pg. 307-9 (Aug 2012) ISSN: 1003-9279 [Print] China
• PMID: 23189853 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Hepatitis Antibodies
• Hepatitis B Antigens

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (blood)
• Child
• Coinfection (blood, diagnosis, immunology, virology)
• Female
• Hepatitis Antibodies (immunology)
• Hepatitis B (blood, diagnosis, immunology, virology)
• Hepatitis B Antigens (blood)
• Hepatitis B virus (immunology, isolation & purification, physiology)
• Hepatitis D (blood, diagnosis, immunology, virology)
• Hepatitis Delta Virus (immunology, isolation & purification)
• Humans
• Male
• Middle Aged
• Young Adult