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Stability of solutions of histamine acid phosphate after sterilization by heating in an autoclave.

Abstract
Histamine acid phosphate (HAP) solutions are used in tests for asthma and also as positive controls in general allergenic testing. Previously these solutions have been sterilized, if at all, by filtration, thus limiting the shelf-life of the preparation and introducing some degree of uncertainty in their use. It is shown here that HAP solutions can be sterilized successfully by heating in an autoclave with little degradation and that subsequent storage of autoclaved solutions indicates a minimum shelf-life of 4 months.
AuthorsC McDonald, J E Parkin, C A Richardson, M Sweidan, D Lonergan, C Chan, R Cohen
JournalJournal of clinical pharmacy and therapeutics (J Clin Pharm Ther) Vol. 15 Issue 1 Pg. 41-4 (Feb 1990) ISSN: 0269-4727 [Print] England
PMID2318916 (Publication Type: Journal Article)
Chemical References
  • Histamine
  • histamine phosphate
Topics
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Histamine (analogs & derivatives)
  • Hot Temperature
  • Spectrophotometry, Ultraviolet
  • Sterilization
  • Time Factors

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