Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSION: These data indicated that levodopa/ benserazide-loaded microspheres could be used to ameliorate the expression of LID by reducing the expression of pGluR1S831 and pGluR1S845 as well as Arc and Penk.
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Authors | Xinxin Yang, Yinghui Chen, Xiaoyun Hong, Na Wu, Lu Song, Weien Yuan, Zhenguo Liu |
Journal | Drug design, development and therapy
(Drug Des Devel Ther)
Vol. 6
Pg. 341-7
( 2012)
ISSN: 1177-8881 [Electronic] New Zealand |
PMID | 23185117
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiparkinson Agents
- Delayed-Action Preparations
- Drug Carriers
- Drug Combinations
- Receptors, AMPA
- benserazide, levodopa drug combination
- Polylactic Acid-Polyglycolic Acid Copolymer
- Polyglycolic Acid
- Lactic Acid
- Levodopa
- Benserazide
- Oxidopamine
- glutamate receptor ionotropic, AMPA 1
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Topics |
- Animals
- Antiparkinson Agents
(administration & dosage, pharmacology, toxicity)
- Benserazide
(administration & dosage, pharmacology, toxicity)
- Blotting, Western
- Delayed-Action Preparations
- Disease Models, Animal
- Down-Regulation
(drug effects)
- Drug Carriers
(chemistry)
- Drug Combinations
- Dyskinesia, Drug-Induced
(etiology, prevention & control)
- Female
- Lactic Acid
(chemistry)
- Levodopa
(administration & dosage, pharmacology, toxicity)
- Microspheres
- Oxidopamine
(toxicity)
- Parkinsonian Disorders
(drug therapy)
- Phosphorylation
(drug effects)
- Polyglycolic Acid
(chemistry)
- Polylactic Acid-Polyglycolic Acid Copolymer
- Rats
- Rats, Sprague-Dawley
- Real-Time Polymerase Chain Reaction
- Receptors, AMPA
(genetics)
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