Rhabdomyosarcoma of the duodenum: report of a case.

Abstract

This report presents a case of primary pleomorphic rhabdomyosarcoma arising in the duodenum. A 63-year-old male with persistent melena was referred for a solid tumor in his right upper abdomen detected using ultrasonography. Gastrofiberscopy revealed a protrusion in the upper part of the duodenum, with a large ulcer on the top of it. Enhanced computed tomography showed that the tumor extended to the pancreas. Pancreaticoduodenectomy was performed, despite the absence of malignant cells in the biopsy specimen, with a preoperative diagnosis of duodenal cancer. The tumor consisted of multiple cell types, and immunohistochemical staining was positive for desmin, HHF-35 and alpha smooth muscle actin. Electron microscopy revealed primitive Z-band structures in the tumor. The final diagnosis was pleomorphic rhabdomyosarcoma of the duodenum. This is the first report of primary rhabdomyosarcoma occurring in the duodenum, confirmed by immunohistochemical staining and electron microscopy.

• Authors: Asahi Sato, Masaji Hashimoto, Jin Moriyama, Marie Hanaoka, Kohta Momose, Keiichi Kinowaki, Sumiyo Ando, Takeshi Fujii, Kenichi Ohashi, Goro Watanabe
• Journal: Surgery today (Surg Today) Vol. 44 Issue 2 Pg. 378-82 (Feb 2014) ISSN: 1436-2813 [Electronic] Japan
• PMID: 23184358 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor
• Desmin
• MyoD Protein
• MyoD1 myogenic differentiation protein

Topics

• Biomarkers, Tumor (analysis)
• Desmin (analysis)
• Duodenal Neoplasms (diagnosis, pathology, surgery, ultrastructure)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• MyoD Protein (analysis)
• Pancreaticoduodenectomy
• Rhabdomyosarcoma (diagnosis, pathology, surgery, ultrastructure)
• Treatment Outcome