[Diagnosis of prospective malignancy of cervix dysplasia using DNA cytometry].

Abstract

134 borderline lesions of the cervix uteri (CIN I/II) were investigated by using the newly developed diagnostic method DNA-image cytometry (MIAMED-DNA, Wild-Leitz, Wetzlar). The demonstration of aneuploid cells served as a marker for prospective malignancy. 18 out of 35 cases, which proved to be CIN III in the follow-up, had a malignant DNA diagnosis. The sensitivity of the diagnostic DNA cytometry for prospective malignancy was therefore 51.4%. All 43 cases with a negative DNA diagnosis proved to be negative in the follow-up, so that the specificity of DNA cytometry was 100%. Suspicious DNA diagnosis in 26% of the cases proved to be CIN III in the follow-up. DNA cytometry seems to be a reliable method to predict the biological behaviour of borderline lesions of the cervix uteri in everyday practice.

• Authors: R Bollmann
• Journal: Geburtshilfe und Frauenheilkunde (Geburtshilfe Frauenheilkd) Vol. 50 Issue 2 Pg. 113-7 (Feb 1990) ISSN: 0016-5751 [Print] Germany
• Vernacular Title: Die Diagnose prospektiver Malignität an zervikalen Dysplasien durch DNA-Zytometrie.
• PMID: 2318402 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Carcinoma in Situ (pathology)
• Cell Transformation, Neoplastic (pathology)
• Cervix Uteri (pathology)
• DNA, Neoplasm (analysis)
• Epithelium (pathology)
• Female
• Flow Cytometry (methods)
• Humans
• Neoplasm Staging
• Ploidies
• Prospective Studies
• Uterine Cervical Dysplasia (pathology)
• Uterine Cervical Neoplasms (pathology)
• Vaginal Smears