Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis.

Abstract

OBJECTIVE:

This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters.

STUDY DESIGN:

Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated.

RESULTS:

Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P < .05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P < .05).

CONCLUSIONS:

Calendula officinalis extract accelerated the healing of oral mucositis in hamsters.

• Authors: Nader Tanideh, Parisa Tavakoli, Mohammad Ali Saghiri, Franklin Garcia-Godoy, Dariush Amanat, Azadeh Andisheh Tadbir, Soleiman Mohammadi Samani, Amin Tamadon
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 115 Issue 3 Pg. 332-8 (Mar 2013) ISSN: 2212-4411 [Electronic] United States
• PMID: 23182376 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• Drug Carriers
• Gels
• Plant Extracts
• Carboxymethylcellulose Sodium
• Fluorouracil

Topics

• Abscess (chemically induced, pathology)
• Animals
• Antimetabolites, Antineoplastic (administration & dosage, adverse effects)
• Calendula
• Carboxymethylcellulose Sodium
• Cricetinae
• Drug Carriers
• Erythema (chemically induced, pathology)
• Fluorouracil (administration & dosage, adverse effects)
• Gels
• Hyperemia (chemically induced, pathology)
• Injections, Intraperitoneal
• Male
• Mesocricetus
• Mouth Diseases (chemically induced, pathology)
• Mouth Mucosa (drug effects, injuries, pathology)
• Oral Hemorrhage (chemically induced, pathology)
• Oral Ulcer (chemically induced, pathology)
• Phytotherapy (methods)
• Plant Extracts (therapeutic use)
• Re-Epithelialization (drug effects)
• Single-Blind Method
• Stomatitis (chemically induced, drug therapy, pathology)
• Time Factors
• Weight Gain
• Wound Healing (drug effects)