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Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients.

Abstract
Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a common autoimmune disease in China. AAVs in the majority of Chinese patients are microscopic polyangiitis with antigenicity to myeloperoxidase. Propylthiouracil is the leading cause of drug-induced AAV. The genetic background and immunological characteristics of ANCA, such as the epitope, IgG subclass and avidity, might contribute to various clinical phenotypes of AAV.
AuthorsPeng-Cheng Xu, Min Chen, Ming-Hui Zhao
JournalClinical and experimental nephrology (Clin Exp Nephrol) Vol. 17 Issue 5 Pg. 705-707 (Oct 2013) ISSN: 1437-7799 [Electronic] Japan
PMID23180038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antibodies, Antineutrophil Cytoplasmic
  • Antithyroid Agents
  • Biomarkers
  • Propylthiouracil
  • Peroxidase
  • Myeloblastin
Topics
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (blood, chemically induced, diagnosis, ethnology, genetics, immunology)
  • Antibodies, Antineutrophil Cytoplasmic (blood)
  • Antithyroid Agents (adverse effects)
  • Asian People (genetics)
  • Biomarkers (blood)
  • China (epidemiology)
  • Genetic Predisposition to Disease
  • Humans
  • Myeloblastin (immunology)
  • Peroxidase (immunology)
  • Phenotype
  • Prognosis
  • Propylthiouracil (adverse effects)
  • Risk Factors

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