Association between low renal function and tooth loss over 5 years.

Abstract

OBJECTIVES:

This longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.

MATERIAL AND METHODS:

Subjects comprised 406 female subjects (55-74 years old) who agreed to participate in a baseline examination and a follow-up examination after 5 years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5 years. Tooth loss over 5 years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5 years.

RESULTS:

Results of multiple logistic regression analysis showed that cystatin C change over 5 years, age, number of remaining teeth at baseline, number of sites with ≥4 mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5 years was 7.70 (p=0.029).

CONCLUSION:

This study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.

• Authors: Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura
• Journal: Gerodontology (Gerodontology) Vol. 31 Issue 2 Pg. 111-6 (Jun 2014) ISSN: 1741-2358 [Electronic] England
• PMID: 23176113 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Gerodontology Society and John Wiley & Sons A/S.

Chemical References

• CST3 protein, human
• Cystatin C
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Aged
• Cystatin C (blood)
• Female
• Follow-Up Studies
• Humans
• Independent Living (statistics & numerical data)
• Japan (epidemiology)
• Longitudinal Studies
• Middle Aged
• Osteoporosis, Postmenopausal (blood, epidemiology)
• Periodontal Attachment Loss (epidemiology)
• Renal Insufficiency (blood, epidemiology)
• Tooth Loss (epidemiology)
• Vitamin D (analogs & derivatives, blood)