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Tryptophan metabolism in vitamin B6-deficient mice.

Abstract
Vitamin B6 deficiency was induced in mice by maintenance for 4 weeks on a vitamin B6-free diet. Tryptophan metabolism was assessed by determining the urinary excretion of tryptophan metabolites, the metabolism of [14C]tryptophan in vivo and the formation of tryptophan and niacin metabolites by isolated hepatocytes. The vitamin B6-deficient animals excreted more xanthurenic acid and 3-hydroxykynurenine, and less of the niacin metabolites N1-methyl nicotinamide and methyl-2-pyridone-4-carboxamide, than did control animals maintained on the same diet supplemented with 5 mg vitamin B6/kg. After intraperitoneal injection of [14C]tryptophan, vitamin B6-deficient mice showed lower liberation of 14CO2 from [methylene-14C]tryptophan and [U-14C]tryptophan than did controls, indicating impairment of kynureninase (EC 3.7.1.3) activity. There was no difference between the two groups of animals in the metabolism of [ring-2-14C]tryptophan. Hepatocytes isolated from the vitamin B6-deficient animals formed more 3-hydroxykynurenine and xanthurenic acid than did cells from control animals, but also formed more NADP and free niacin.
AuthorsD A Bender, E N Njagi, P S Danielian
JournalThe British journal of nutrition (Br J Nutr) Vol. 63 Issue 1 Pg. 27-36 (Jan 1990) ISSN: 0007-1145 [Print] England
PMID2317476 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Formates
  • formic acid
  • Tryptophan
  • Alanine
Topics
  • Alanine (metabolism)
  • Animals
  • Cells, Cultured
  • Formates (metabolism)
  • Liver (metabolism)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Tryptophan (metabolism)
  • Vitamin B 6 Deficiency (metabolism, urine)
  • Weight Gain (physiology)

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