Abstract | BACKGROUND: METHODS: This was a prospective randomized open-label blinded end point (PROBE) study. Forty patients with hypercholesterolemia and IFG were randomized to receive rosuvastatin 5 mg/day plus colesevelam 3.75 g/day (RC, n=20) or rosuvastatin 10 mg (R, n=20) for 3 months. The primary end point was the difference in the change of homeostasis model assessment of insulin resistance (HOMA-IR) index between the groups. RESULTS: HOMA-IR index significantly decreased in the RC group (-32%, P=0.04 vs. baseline) but nonsignificantly increased (+15%, P=NS) in the R group. Insulin levels decreased in the RC group (-26%, P=NS) but increased in the R group (+15%, P=NS). Both changes in HOMA-IR and insulin differed significantly between groups (both p<0.05). Glucose levels decreased in the RC group (-5%, P=NS), whereas they remained unaltered in the R group. Similar reductions in low-density lipoprotein cholesterol were observed in both groups (-45%; P<0.001 vs. baseline). Triglycerides remained unchanged in the RC group but decreased in the R group (-24%, P<0.001 vs. baseline and P=0.02 vs. RC group). CONCLUSIONS:
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Authors | Matilda Florentin, Evangelos N Liberopoulos, Christos V Rizos, Anastazia A Kei, George Liamis, Michael S Kostapanos, Moses S Elisaf |
Journal | Metabolic syndrome and related disorders
(Metab Syndr Relat Disord)
Vol. 11
Issue 3
Pg. 152-6
(Jun 2013)
ISSN: 1557-8518 [Electronic] United States |
PMID | 23170931
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anticholesteremic Agents
- Biomarkers
- Blood Glucose
- Fluorobenzenes
- Pyrimidines
- Sulfonamides
- Allylamine
- Rosuvastatin Calcium
- Colesevelam Hydrochloride
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Topics |
- Aged
- Allylamine
(administration & dosage, adverse effects, analogs & derivatives)
- Anticholesteremic Agents
(administration & dosage, adverse effects)
- Biomarkers
(blood)
- Blood Glucose
(drug effects, metabolism)
- Colesevelam Hydrochloride
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Fasting
(blood)
- Female
- Fluorobenzenes
(administration & dosage, adverse effects)
- Glucose Intolerance
(blood, complications, drug therapy)
- Humans
- Hypercholesterolemia
(blood, complications, drug therapy)
- Insulin Resistance
- Male
- Middle Aged
- Prediabetic State
(blood, drug therapy)
- Pyrimidines
(administration & dosage, adverse effects)
- Rosuvastatin Calcium
- Sulfonamides
(administration & dosage, adverse effects)
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