[Research progress of bone morphogenetic protein and liability of ossification of posterior longitudinal ligament].

Abstract

OBJECTIVE:

To review the research progress of bone morphogenetic protein (BMP) and the liability of ossification of the posterior longitudinal ligament (OPLL).

METHODS:

Recent literature concerning BMP and the liability of OPLL was reviewed, analysed, and summarized.

RESULTS:

The single nucleotide polymorphisms (SNPs) of BMP gene may produce a minor cumulative effect and increase individual susceptibility to OPLL. A variety of environmental factors can promote the occurrence and development of OPLL by increasing the expression of BMP gene.

CONCLUSION:

The SNPs of BMP gene may increase individual susceptibility to OPLL. However, interaction of cumulative effect of the SNPs and environmental factors can promote the liability to OPLL.

• Authors: Zhao Fang, Tianwei Sun, Sandip Kumar Yadav
• Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery (Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi) Vol. 26 Issue 10 Pg. 1255-8 (Oct 2012) ISSN: 1002-1892 [Print] China
• PMID: 23167115 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Bone Morphogenetic Protein 2
• Bone Morphogenetic Protein 4
• Bone Morphogenetic Proteins

Topics

• Bone Morphogenetic Protein 2 (genetics)
• Bone Morphogenetic Protein 4 (genetics)
• Bone Morphogenetic Proteins (genetics)
• Gene Conversion
• Genetic Linkage (genetics)
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Ossification of Posterior Longitudinal Ligament (genetics)
• Osteoblasts (metabolism)
• Polymorphism, Single Nucleotide